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AdipoGen Life Sciences
Pellitorine
35
CHF
CHF 35.00
In stock
AG-CN2-0009-M0011 mgCHF 35.00
AG-CN2-0009-M0055 mgCHF 105.00
AG-CN2-0009-M02525 mgCHF 350.00
| Product Details | |
|---|---|
| Synonyms | (2E,4E)-N-(2-Methylpropyl)-2,4-decadienamide; BRN 1725967 |
| Product Type | Chemical |
| Properties | |
| Formula |
C14H25NO |
| MW | 223.4 |
| Merck Index | 14: 7073 |
| CAS | 18836-52-7 |
| Source/Host Chemicals | Synthetic. Originally isolated from roots of Anacyclus pryrethrum and fruits of Piper nigrum. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Yellow to beige solid. |
| Solubility | Soluble in 100% ethanol, methanol, DMSO or dichloromethane. Sparingly soluble in water. |
| InChi Key | MAGQQZHFHJDIRE-BNFZFUHLSA-N |
| Smiles | [H]N(CC(C)C)C(=O)C(\[H])=C(/[H])\C(\[H])=C(/[H])CCCCC |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Tingling-inducing agent. Excellent stable model compound for sensory studies [3]. Exerts same profile as the unstable compound hydroxy-α-sanshool.
- Shows larvicidal, antimycobacterial and antituberculosis activity [1, 2, 4].
- α-Glucosidase inhibitor used in diabetes mellitus, cancer, infection and inflammatory research [5].
- ACAT (Acyl-CoA cholesteryl acyl transferase) inhibitor [6].
- Potential anti-cancer lead compound [7].
- Anti-thrombotic [8].
- Anti-septic [9].
- Antiprotozoal, antimalarial activity [10].
- Antagonist of the TRPV1 [11].
Product References
- Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species: I.K. Park, et al.; J. Agric. Food Chem. 50, 1866 (2002)
- Chemical constituents and bioactivity of Piper sarmentosum: T. Rukachaisirikul, et al.; J. Ethnopharmacol. 93, 173 (2004)
- Stereoselective Enzymatic Synthesis of cis-Pellitorine, a Taste Active Alkamide Naturally Occurring in Tarragon: P. J. Ley, et al.; Eur. J. Org. Chem. 2004, 5135
- Chemical constituents of the roots of Piper sarmentosum: P. Tuntiwachwuttikul, et al.; Chem. Pharm. Bull. (Tokyo) 54, 149 (2006)
- HPLC assisted chemobiological standardization of alpha-glucosidase-I enzyme inhibitory constituents from Piper longum Linn - An Indian medicinal plant: S.V. Pullela, et al.; J. Ethnopharmacol. 108, 445 (2006)
- ACAT inhibition of alkamides identified in the fruits of Piper nigrum: M.C. Rho, et al.; Phytochemistry 68, 899 (2007)
- Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum: G.C. Ee, et al.; Molecules 15, 2398 (2010)
- Antithrombotic activities of pellitorine in vitro and in vivo: S.K. Ku, et al.; Fitoterapia 91, 1 (2013)
- Anti-septic effects of pellitorine in HMGB1-induced inflammatory responses in vitro and in vivo: S.K. Ku, et al.; Inflammation 37, 338 (2014)
- Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents: J.B. Althaus, et al.; Molecules 19, 6428 (2014)
- Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1: Z. Olah, et al.; Phytomed. 34, 44 (2017)
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