Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Convulxin
CHF 890.00
In stock
AG-CN2-0465-C05050 µgCHF 890.00
| Product Details | |
|---|---|
| Synonyms | CVX |
| Product Type | Chemical |
| Properties | |
| MW | ~84kDa |
| CAS | 37206-04-5 |
| Source/Host Chemicals | Isolated from Crotalus durissus terrificus snake venom. |
| Purity Chemicals | >90% SDS-PAGE (partially purified by multi-step chromatography). |
| Appearance | Lyophilized. |
| Solubility | Soluble in organic buffer (HEPES). |
| Reconstitution | Reconstitute in 10mM HEPES buffer, pH 7.2. (We recommend adding a carrier protein such as BSA to the reconstitution buffer and any subsequent dilution buffers to prevent absorption on plastic surfaces.) |
| Biological Activity |
<50ng/ml (minimal concentration to induce maximum activation of washed human platelets). |
| Other Product Data |
Stock solutions are stable for 8 hours at +20°C, for 2 days at +4°C or for 1 month when stored at -80°C. |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Protocols |
 Download PDF |
| MSDS |
Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Glycoprotein GPVI receptor agonist. Can be used for studies on platelet receptors.
- Activates mammalian platelets via binding and clustering of GPVI-receptors under physiological conditions. Occupation and clustering of GPVI activates Src family kinases, phosphorylates Fc receptor γ-chain and activates p72SYK that is critical for downstream activation of platelets.
- Causes cardiovascular and respiratory disturbances.
- Prostaglandins are strong inhibitors of convulxin-induced aggregation.
- Heterodimeric C-type lectin. Disulfide linked heterodimer consisting of homologous α and β chains. The heterodimers are additionally linked by disulfide bridges to form cyclic α(4)β(4)heterotetramers.
Product References
- Convulxin, a new toxin from the venom of the South American rattlesnake Crotalus durissus terrificus: J. Prado-Franceschi & O.V. Brazil; Toxicon 19, 875 (1981)
- Convulxin, a potent platelet-aggregating protein from Crotalus durissus terrificus venom, specifically binds to platelets: I.M. Francischetti, et al.; Toxicon 35, 1217 (1997)
- Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor: J. Polgar, et al.; J. Biol. Chem. 272, 13576 (1997)
- Convulxin-induced platelet adhesion and aggregation: involvement of glycoproteins VI and IaIIa: M. Jandrot-Perrus, et al.; Platelets 9, 207 (1998)
- Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases: M. Cicmil, et al.; J. Biol. Chem. 275, 27339 (2000)
- Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin: B.T. Atkinson, et al.; Eur. J. Biochem. 268, 5242 (2001)
- Convulxin binding to platelet receptor GPVI: competition with collagen related peptides: F. Niedergang, et al.; BBRC 273, 246 (2002)
- Convulxin binds to native, human glycoprotein Ib alpha: S. Kanaji, et al.; J. Biol. Chem. 278, 39452 (2003)
Related Products
