Compounds powered by Lipodisq

Lipodisq™ are novel lipid/polymer nanoparticles that have been developed as mimics of naturally-occurring high-density lipoproteins (HDL). Lipodisq™ particles are in the size range of 11 to 40 nm in diameter enabling enhanced penetration and diffusion into membranes. These nanodisc lipid particles are composed of a hydrophilic shell and hydrophobic core in which hydrophobic active agents can be carried and protected.

The size and shape of the chaperone molecule is a critical factor in Lipodisq™ formation and also defines the properties of the particle, i.e. particle size and/or its biodegradability. Internal properties of the phospholipid membrane support the disposition and stabilization of drug molecule candidates and preserve the native conformation of membrane-bound molecules. The resulting encapsulated actives are rendered water-soluble and optimized for intracellular penetration/delivery via endosomal uptake mechanisms.

FIGURE: Nanoparticle (11-40 nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilized by an annular chaperone molecule.

LITERATURE REFERENCES

1. Responsive Hydrophobically Associating Polymers: A Review of Structure and Properties: S.R. Tonge & B.J. Tighe; Adv. Drug Deliv. Rev. 53, 109 (2001)
2. Detergent-free formation and physico-chemical characterization of nanosized lipidpolymer complexes: Lipodisq; M.C. Orwick, et al.; Angew. Chem. 51, 4653 (2012)
   
3. The styrene–maleic acid copolymer: a versatile tool in membrane research: J.M. Doerr, et al.; Eur. Biophys. J. 45, 3 (2016)
4. Effects of charged lipids on the physicochemical and biological properties of lipid–styrene maleic acid copolymer discoidal particles: M. Tanaka, et al.; Biochim. Biophys. Acta. Biomembr. 1862, 183209 (2020)
5. Physico-chemical Characterization, Toxicity and In Vivo Biodistribution Studies of a Discoidal, Lipid-Based Drug Delivery Vehicle: Lipodisq Nanoparticles Containing Doxorubicin: M.L. Torgersen, et al.; J. Biomed. Nanotechnol. 16, 41 (2020)

Not for cosmetic, diagnostic or therapeutic human or veterinary use!

Compounds powered by Lipodisq™ Features

• Actives in Lipodisq™ are biosynthetic water-soluble nanodiscs prepared under SOPs using selected optimized lipid compositions for stable, high-loading capacity of encapsulated active ingredients.
• Actives in Lipodisq™ are detergent-free nano-formulations made of styrene-maleic acid copolymer-lipid particles (SMALP).
• Actives in Lipodisq™ retain the biological activity of the active compound with enhanced bioavailability.
• Lipodisq™ solutions show a good safety profile and are suitable for in vitro and in vivo investigations.

SPECIAL Features of Innaxon Compounds powered by Lipodisq™ 

• >10¹¹ particles per ml as determined by Dynamic Light Scattering (DLS).
• Tested in cell culture (human macrophage cell line as tested by MTT viability test).
• Formulations are soluble in water, PBS, Tris and other physiological solutions as formulated in a proprietary, thermostable, aqueous lipid nanoparticulate formulation.
• Formulations are certified sterile solutions with a physiological pH range.

Selection of Antiviral and Immunomodulating Compounds powered by Lipodisq™:

New Ready-to-use Nano-formulated Aqueous Solutions (1 mg/ml) 

LEGAL CLAIM: The use of styrene maleic acid copolymer-phospholipid nanoparticles (Lipodisq™ Technology) and active agents contained therein is covered by one or more of the following patents owned by Malvern Cosmeceutics Limited: AU2006253886, CA2611144, CN101184473B, EP1890675, GB2426703, IN261468, JP5142898, US8623414 and WO/2021/005340A1 pending.

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Innaxon Lipodisq Product Flyer 2022 Lipodisq™ are novel lipid/polymer nanoparticles that have been developed as mimics of naturally-occurring high-density lipoproteins (HDL). Innaxon's Actives in Lipodisq™ which are biosynthetic, detergent-free, water-soluble novel lipid/polymer nanoparticles with stable encapsulated active ingredients, that retain the biological activity with enhanced bioavailability. Download the Product Flyer		Download