DMPC (1,2-Dimyristoyl-sn-glycero-3-phosphocholine) (14:0 PC)

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid utilized in liposomes and lipid bilayers for the study of biological membranes. Its utility extends to investigating the influence of lipids on enzymatic activity and protein function when formulated into nanodiscs, LNP or liposomes. Phosphatidylcholines are zwitterionic phospholipids containing choline as part of the polar head group. At physiological pH, phosphocholine has an overall neutral charge. Furthermore, this compound has proven valuable in exploring the interplay between lipids and proteins, elucidating their interactions, and unraveling the impact of lipids on protein structure and functionality.

Lipodisq™ are nanosized lipid-based discoidal particles that can be manufactured with P(SMA)/ SMALP and lipids such as DMPC (14:0 PC) (DMPC: IAX-700-400) to incorporate hydrophobic, poorly water-soluble active compounds, such as peptides, lipids, lipoproteins, transmembrane proteins and glycolipids. Applications of Lipodisq™ include functional and structural characterisation of the cargo and drug delivery with improved bioavailability, and biological half-life in vivo (PD/PK) or delivery of antigens preserved in their native comformation for immunization purposes.