Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
ANGPTL6 (human) ELISA Kit
670
CHF
CHF 670.00
In stock
AG-45A-0016YEK-KI0196 wellsCHF 670.00
Figure 1: Standard curve
| Product Details | |
|---|---|
| Synonyms | Angiopoietin-like Protein 6; AGF; Angiopoietin-related Growth Factor |
| Product Type | Kit |
| Properties | |
| Application Set | Quantitative ELISA |
| Specificity | Detects human ANGPTL6. Does not cross-react with human ANGPTL3, human ANGPTL4 or human ANGPTL7. |
| Crossreactivity | Human |
| Quantity | 1 x 96 wells |
| Sensitivity | 1.2ng/ml |
| Range | 1.56 to 100ng/ml |
| Sample Type |
Cell Culture Supernatant Plasma Serum |
| Assay Type | Sandwich |
| Detection Type | Colorimetric |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use. |
| Documents | |
| Manual |
 Download PDF |
| MSDS |
Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Seven proteins containing an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristics of angiopoietins, have been identified and therefore designated angiopoietin-like proteins 1-7 (ANGPTL 1-7). ANGPTL3 and ANGPTL6 (Angiopoietin-related growth factor; AGF), among others, function to regulate angiogenesis and also appear to directly regulate lipid, glucose and energy metabolism. The serum levels of ANGPTL6 are significantly increased in obese humans, patients with type 2 diabetes mellitus (T2DM) and in metabolic syndrome. Therefore, ANGPTL6 may be a novel biomarker for metabolic diseases and may provide a novel therapeutic approach to counteract obesity, T2DM and insulin resistance.
Product References
- Serum levels of angiopoietin-related growth factor are increased in preeclampsia: H. Stepan, et al.; Am. J. Hypertens. 22, 314 (2009)
- Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis: T. Ebert, et al.; Metabolism 58, 547 (2009)
- Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome: J. Namkung, et al.; Metabolism 60, 564 (2011)
- A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6: S. Marchiò, et al.; EMBO Mol. Med. 4, 1156 (2012)
- Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease: E.B. Beck, et al.; Eur. J. Prev. Cardiol. 19, 412 (2012)
- Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014)
- Adipokines may mediate the relationship between resting metabolic rates and bone mineral densities in obese women: S. Moradi, et al.; Osteopor. Int. 28, 1619 (2017)
- Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm: R. Bourcier, et al.; Am. J. Hum. Genet. 102, 133 (2018)
- Increased serum angiopoietin-like 6 ahead of metabolic syndrome in a prospective cohort study: J. Namkung, et al.; Diabetes Metab. J. 43, 521 (2019)
- Serum Angiopoietin-like Protein 6, risk of type 2 diabetes, and response to hyperglycemia: A prospective cohort study: K.C. Fan, et al.; J. Clin. Endocrinol. Metab. 105, e1949 (2020)
- Interplay between adipose tissue secreted proteins, eating behavior and obesity: M. Würfel, et al.; Eur. J. Nutr. 61, 885 (2022)
Related Products
