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Potent and selective antagonist for mGluR5 [1, 2].
5-fold higher anxiolytic activity than MPEP [3].
Antidepressant [4].
Neuroprotective [5].
Produces antiparkinsonian-like effects in rats [6].
Product References
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity: J. Med. Chem. 46 204 (2003)
Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology 47, 342 (2004)
Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP: P.M. Lea IV & A.I. Faden; CNS Drug Rev. 12, 149 (2006)
Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav. 81, 901 (2005)
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol. 145, 527 (2005)
MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology 49, 447 (2005)
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