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AdipoGen Life Sciences
1-Azakenpaullone
95
CHF
CHF 95.00
In stock
AG-CR1-0035-M0011 mgCHF 95.00
AG-CR1-0035-M0055 mgCHF 285.00
| Product Details | |
|---|---|
| Synonyms | 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H10BrN3O |
| MW | 328.2 |
| CAS | 676596-65-9 |
| Purity Chemicals | ≥98% (HPLC, NMR) |
| Appearance | Off-white to tan solid. |
| Solubility | Soluble in DMSO; insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Other Product Data |
Stock solutions are stable for up to 6 months when stored at -20°C. |
| InChi Key | NTSBZVCEIVPKBJ-UHFFFAOYSA-N |
| Smiles | BrC1=CC2=C(NC3=C2CC(=O)NC2=C3N=CC=C2)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and ATP-competitive GSK-3β (glycogen synthase kinase-3β) inhibitor (IC50 = 18 nM) [1, 2].
Product References
- 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta: C. Kunick, et al.; Bioorg. Med. Chem. Lett.14, 413 (2004)
- Studying the mechanism that enables paullones to selectively inhibit glycogen synthase kinase 3 rather than cyclin-dependent kinase 5 by molecular dynamics simulations and free-energy calculations: Q. Chen, et al.; J. Mol. Model. 17, 795 (2011)
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