β-Mannosylceramide

More Information
Product Details
Synonyms	β-ManCer; β-Mannosyl Ceramide; (2S,3S,4R)-2-Amino-N-hexacosanoyl-1-O-(β-D-mannopyranosyl)-1,3,4-octadecanetriol
Product Type	Chemical
Properties
Formula	C₅₀H₉₉NO₉
MW	858.3
CAS	1334332-65-8
Purity Chemicals	≥95% (TLC, NMR)
Appearance	White to off-white solid.
Solubility	Soluble in pyridine or warm DMSO. Insoluble in water.
Identity	Determined by ¹H-NMR.
Other Product Data	Natural killer T cells (NKT cells) are important regulators of the immune system. They share properties of both innate as well as adaptive immunity. They express T cell receptors (TCR) on their surface consisting of an invariable α-chain and a somewhat variable β-chain. The majority of NKT cells express the invariable α-chain Vα14-Jα18 (Vα14) in mouse or its homolog in humans Vα24-Jα18 (Vα24). NKT cells expressing the invariant Vα19-Jα26 TCR α-chain (Vα19 NKT cells) have been found in peripheral blood lymphocytes and in the liver.
InChi Key	VQFKFAKEUMHBLV-JDMIZZMOSA-N
Smiles	CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](COC1OC(CO)C(O)C(O)C1O)[C@H](O)[C@H](O)CCCCCCCCCCCCCC
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After reconstitution, prepare aliquots and store at -20°C. Aliquot into glass vials.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Potent stimulator of invariant natural killer T (iNKT) cells.
Induces strong antitumor immunity through a nitric oxide (NO) and TNF-α dependent mechansim, different compared to the IFN-γ dependent mechanism of α-GalCer (AG-CN2-0014).
Does not induce anergy of iNKT cells.

Product References

Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity: J.J. O'Konek, et al.; J. Clin. Invest. 121, 683 (2011)
NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma: S.R. Mattarollo, et al.; Blood 120, 3019 (2012)
β-mannosylceramide activates type I natural killer t cells to induce tumor immunity without inducing long-term functional anergy: J.J. O'Konek, et al.; Clin. Cancer Res. 19, 4404 (2013)

Call	+41 61 926 6040
Fax	+41 61 926 6049