anti-MHC Class I (human), mAb (3F10)

Human MHC Class I (HLA-A, B & C) molecules are expressed on nearly all nucleated cells. MHC Class I molecules consist of heterodimers of a highly polymorphic transmembrane α chain and an invariant β chain. MHC Class I molecules bind to endogenously synthesized peptides of about 8-10 amino acids which are presented to CD8+ T cells. Evidence indicates exogenously derived peptides are also presented by MHC Class I molecules.