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Chemodex
Laurdan
183
CHF
CHF 183.00
In stock
CDX-D0098-M05050 mgCHF 183.00
CDX-D0098-M250250 mgCHF 732.00
CDX-D0098-G0011 gCHF 2'510.00
| Product Details | |
|---|---|
| Synonyms | N,N-Dimethyl-6-dodecanoyl-2-naphthylamine |
| Product Type | Chemical |
| Properties | |
| Formula | C24H35NO |
| MW | 353.54 |
| CAS | 74515-25-6 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Light yellow solid. |
| Solubility | Soluble in methanol, DMF or acetonitrile. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | JHDGGIDITFLRJY-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCC(=O)C1=CC2=CC=C(C=C2C=C1)N(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
N,N-Dimethyl-6-dodecanoyl-2-naphthylamine (Laurdan) is used as an environmentally sensitive probe for the labeling of plasma membranes. The lauroyl-sidechain integrates into the hydrophobic core of biological membranes, the polar fluorescent moiety is at level of the glycerol-backbone. Dipolar relaxation processes of the naphtylamine-moiety with neighboring polar molecules lead to wavelength-shifts of the emission-spectra. The physical state of the membrane and effects of temperature, cholesterol or ethanol on various membrane-systems have been monitored.
Product References
(1) S.S. Antollini et al.; Meth. Mol. Biol. 400, 531 (2007) | (2) Y.L. Zhang et al.; Biochem. Biophys. Res. Comm. 347(3), 838 (2006) | (3) L. Bagatolli et al.; Biochimica et Biophysica Acta 1325, 80 (1997) | (4) L.I. Hellgren et al.; Plant Physiol. Biochem. 34(4), 455 (1996) | (5) G. Weber et al.; Biochemistry 18(14), 3075 (1979)
Role of Negatively Charged Lipids Achieving Rapid Accumulation of Water-Soluble Molecules and Macromolecules into Cell-Sized Liposomes against a Concentration Gradient: H. Sugiyama, et al.; Langmuir ahead of print (2021)