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Chemodex
6-(Dimethylamino)purine
135
CHF
CHF 135.00
In stock
CDX-D0318-G0011 gCHF 135.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula | C7H9N5 |
| MW | 163.18 |
| CAS | 938-55-6 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMF. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | BVIAOQMSVZHOJM-UHFFFAOYSA-N |
| Smiles | CN(C)C1=C2NC=NC2=NC=N1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-α upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).
Product References
(1) H. Bredereck et al.; Berichte der Deutschen Chemischen Gesellschaft 73B, 1058-65 (1940) | (2) J. Vesely et al.; European Journal of Biochemistry 224(2), 771-86 (1994) | (3) P. Chesne et al.; Nature Biotechnology 20(4), 366-369 (2002)