4-Hydroxyphenylpyruvic acid

Specifications / Handling

More Information
Product Details
Synonyms	3-(4-Hydroxyphenyl)-2-oxopropanoic acid; 4-HPPA; p-Hydroxyphenylpyruvic acid
Product Type	Chemical
Properties
Formula	C₉H₈O₄
MW	180.16
CAS	156-39-8
Source/Host Chemicals	Synthetic
Purity Chemicals	≥98% (HPLC)
Appearance	Light brown crystalline.
Solubility	Soluble in water, ethanol (50 mg/ml), ether or methanol.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	KKADPXVIOXHVKN-UHFFFAOYSA-N
Smiles	OC(=O)C(=O)CC1=CC=C(O)C=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.

Product References

(1) C.H. Doy, et al.; Nature 186, 529 (1960) | (2) W. Loffelhardt & H. Kindl; FEBS Lett 104, 332 (1979) | (3) K. Tomoeda, et al.; Mol. Genet. Metab. 71, 506 (2000) | (4) E. van Dyk & P. Pretorius; BBRC 338, 815 (2005)

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