PTACH

Specifications / Handling

More Information
Product Details
Synonyms	NCH 51; Cpd 51; S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate
Product Type	Chemical
Properties
Formula	C₂₀H₂₆N₂O₂S₂
MW	390.56
CAS	848354-66-5
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥95% (HPLC)
Appearance	White crystals.
Solubility	Soluble in DMSO (25mg/ml).
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	MDYDGUOQFUQOGE-UHFFFAOYSA-N
Smiles	CC(C)C(=O)SCCCCCCC(=O)NC1=NC(=CS1)C1=CC=CC=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Non-hydroxamate HDAC inhibitor (HDACi) (IC50: 32, 48 and 41nM for HDAC4, HDAC1 and HDAC6, respectively). Cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor. Predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group. Shown to exhibit comparable antiproliferative and apoptotic activity as SAHA against various cancer cell lines. Inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1μM). Also reactivates latent HIV-1 gene expression.

Product References

(1) T. Suzuki, et al.; J. Med. Chem. 48, 1019 (2005) | (2) T. Sanda, et al.; Leukemia 21, 2344 (2007) | (3) T. Suzuki, et al.; Bioorg. Med. Chem. Lett. 17, 1558 (2007) | (4) A.F. Victoriano, et al.; FEBS Lett. 585, 1103 (2011)

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