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SynKinase
IC87114
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | IC-87114 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H19N7O |
| MW | 397.4 |
| CAS | 371242-69-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PI3K | Kinase Group: Lipid Kinase | Substrate: Lipid Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | GNWHRHGTIBRNSM-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kδ. IC(50) values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10µM to 200µM. IC87114 can selectively inhibit cellular migration but not adhesion as well as cellular polarization. More recent work has shown the PIK3δ inhibition also plays a role in autoimmune disease suppression.
Product References
- Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement: C. Sadhu, et al.; J. Immunol. 170, 2647 (2003)
- The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors: A. Berndt, et al.; Nat. Chem. Biol. 6, 117 (2010)
- PI3Kdelta and PI3Kgamma as targets for autoimmune and inflammatory diseases: T.D. Cushing, et al.; J. Med. Chem. 55, 8559 (2012)
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