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SynKinase
TAK-715
CHF 0.00
In stock
SYN-1087-M0011 mgCHF 99.00
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SYN-1087-M05050 mgCHF 653.00
SYN-1087-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | TAK715 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H21N3OS |
| MW | 399.5 |
| CAS | 303162-79-0 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: p38 | Kinase Group: CMGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | HEKAIDKUDLCBRU-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
TAK-715 is a potent specific inhibitor of the p38α MAP kinase with an IC(50) of 7.1nM. It is approximately 30-fold more selective for p38α over p38β. It shows no inhibition of p38γ/δ.
Product References
- Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent: S. Miwatashi, et al.; J. Med. Chem. 48, 5966 (2005)