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SynKinase
GDC-046
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | GDC046 |
| Product Type | Chemical |
| Properties | |
| Formula | C16H13Cl2N3O2 |
| MW | 350.2 |
| CAS | 1258292-64-6 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: TYK2 | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | IAFNAEGXTKTGHN-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
GDC046 is a potent selective TYK2 inhibitor (Ki=4.8nm) versus JAK1 (Ki=84nm) and JAK2 (Ki=28nm). It is a lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile.
Product References
- Lead identification of novel and selective TYK2 inhibitors: J. Liang, et al.; Eur. J. Med. Chem. 67, 175 (2013)