AdipoGen Life Sciences

anti-BAFF-R (mouse), mAb (9B9) (ATTO 647N)

CHF 440.00

In stock

AG-20B-0034TS-T100100 testsCHF 440.00

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Product Details
Synonyms	BAFF Receptor; BR3; BlySR3; CD268; TNFRSF13C
Product Type	Monoclonal Antibody
Properties
Clone	9B9
Isotype	Rat IgG2b
Source/Host	Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen	Y3 cells transfected with mouse BAFF-R.
Label/Conjugates	ATTO 647N
Application	Flow Cytometry Functional Application: Depletion of B cells in vivo. Optimal conditions must be determined individually for each application. Definition for 1 test: 1μl of labeled antibody in 200μl of Flow Cytometry buffer (see online protocol).
Crossreactivity	Mouse
Specificity	Recognizes mouse BAFF-R.
Purity	≥95% (SDS-PAGE)
Purity Detail	Protein G-affinity purified.
Concentration	1mg/ml
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Other Product Data	New ATTO-fluorescent antibodies show increased photostability, outstanding brightness and intense signals. ATTO dyes are thermally stable, resistant to environmental changes and show no significant isomerization. ATTO 647N shows red fluorescence (λabs (max): 645nm, λem (max): 669nm, εmax: 120’000).
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Do not freeze. Protect from light.
Use/Stability	Keep conjugated formats at +4°C. Stable for at least 1 year after receipt when stored at +4°C.
Documents
Protocols	Download PDF
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF-R signaling is essential for B cell development, survival and humoral immune responses.

Product References

Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells: M. Rauch, et al.; PLoS ONE 4, e5456 (2009)
BAFF-R expression correlates with positive selection of immature B cells: R. Tussiwand, et al.; Eur. J. Immunol. 42, 206 (2012)
PD-L1hi B cells are critical regulators of humoral immunity: A.R. Khan, et al.; Nat. Commun. 6, 5997 (2015)
The unknown aspect of BAFF: Inducing IL-35 production by a CD5⁺CD1d^hiFcγRIIb^hi regulatory B-Cell subset in lupus: Y. Zhang, et al.; J. Invest. Dermatol. 137, 2532 (2017)
B-1a lymphocytes promote oligodendrogenesis during brain development: S. Tanabe & T. Yamashita; Nature Neurosci. 21, 506 (2018)

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