AdipoGen Life Sciences

anti-BAFF-R (mouse), mAb (9B9)

CHF 410.00

In stock

AG-20B-0034-C100100 µgCHF 410.00

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Product Details
Synonyms	BAFF Receptor; BR3; BlySR3; CD268; TNFRSF13C
Product Type	Monoclonal Antibody
Properties
Clone	9B9
Isotype	Rat IgG2b
Source/Host	Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen	Y3 cells transfected with mouse BAFF-R.
Application	Flow Cytometry Functional Application: Depletion of B cells in vivo. Optimal conditions must be determined individually for each application.
Crossreactivity	Mouse
Specificity	Recognizes mouse BAFF-R.
Purity	≥95% (SDS-PAGE)
Purity Detail	Protein G-affinity purified.
Endotoxin Content	<0.01EU/μg purified protein (LAL test; Lonza).
Concentration	1mg/ml
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Isotype Negative Control	Rat IgG2b Isotype Control
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF-R signaling is essential for B cell development, survival and humoral immune responses.

Product References

Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells: M. Rauch, et al.; PLoS ONE 4, e5456 (2009)
BAFF-R expression correlates with positive selection of immature B cells: R. Tussiwand, et al.; Eur. J. Immunol. 42, 206 (2012)
PD-L1hi B cells are critical regulators of humoral immunity: A.R. Khan, et al.; Nat. Commun. 6, 5997 (2015)
The unknown aspect of BAFF: Inducing IL-35 production by a CD5⁺CD1d^hiFcγRIIb^hi regulatory B-Cell subset in lupus: Y. Zhang, et al.; J. Invest. Dermatol. 137, 2532 (2017)
B-1a lymphocytes promote oligodendrogenesis during brain development: S. Tanabe & T. Yamashita; Nature Neurosci. 21, 506 (2018)

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