anti-BAFF-R (mouse), mAb (9B9)

CHF 410.00
In stock
AG-20B-0034-C100100 µgCHF 410.00
More Information
Product Details
Synonyms BAFF Receptor; BR3; BlySR3; CD268; TNFRSF13C
Product Type Monoclonal Antibody
Properties
Clone 9B9
Isotype Rat IgG2b
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Y3 cells transfected with mouse BAFF-R.
Application Flow Cytometry
Functional Application: Depletion of B cells in vivo.
Optimal conditions must be determined individually for each application.
Crossreactivity Mouse
Specificity Recognizes mouse BAFF-R.
Purity ≥95% (SDS-PAGE)
Purity Detail Protein G-affinity purified.
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration 1mg/ml
Formulation Liquid. In PBS containing 0.02% sodium azide.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF-R signaling is essential for B cell development, survival and humoral immune responses.

Product References
  1. Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells: M. Rauch, et al.; PLoS ONE 4, e5456 (2009)
  2. BAFF-R expression correlates with positive selection of immature B cells: R. Tussiwand, et al.; Eur. J. Immunol. 42, 206 (2012)
  3. PD-L1hi B cells are critical regulators of humoral immunity: A.R. Khan, et al.; Nat. Commun. 6, 5997 (2015)
  4. The unknown aspect of BAFF: Inducing IL-35 production by a CD5+CD1dhiFcγRIIbhi regulatory B-Cell subset in lupus: Y. Zhang, et al.; J. Invest. Dermatol. 137, 2532 (2017)
  5. B-1a lymphocytes promote oligodendrogenesis during brain development: S. Tanabe & T. Yamashita; Nature Neurosci. 21, 506 (2018)
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