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AdipoGen Life Sciences
anti-Progranulin (human), pAb
320
CHF
CHF 320.00
In stock
AG-25A-0112-C100100 µgCHF 320.00
Figure 1: Western blot analysis using anti-Progranulin (human), pAb (Prod. No. AG-25A-0112) at 1:2'000 dilution.
1: Human Progranulin (FLAG®-tagged) (50ng).
2: Human Progranulin (tag-free) (100ng).
3: Human Granulin C (FLAG®-tagged) (50ng).
4: Human Granulin F (FLAG®-tagged) (50ng).
5: Mouse Progranulin (FLAG®-tagged) (50ng).
6: Unrelated Protein (FLAG®-tagged).
1: Human Progranulin (FLAG®-tagged) (50ng).
2: Human Progranulin (tag-free) (100ng).
3: Human Granulin C (FLAG®-tagged) (50ng).
4: Human Granulin F (FLAG®-tagged) (50ng).
5: Mouse Progranulin (FLAG®-tagged) (50ng).
6: Unrelated Protein (FLAG®-tagged).
Figure 2: Immunohistochemical staining of progranulin using anti-Progranulin (human), pAb (Prod. No. AG-25A-0112) in formalin-fixed and paraffin-embedded (FFPE) human pancreas tissue (10µg/ml).
| Product Details | |
|---|---|
| Synonyms | Proepithelin; PEPI; PC Cell-derived Growth Factor |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Guinea pig |
| Immunogen/Antigen | Recombinant human progranulin. |
| Application |
ELISA: (direct and indirect: 1:2’000-1:5’000) Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS. |
| Crossreactivity | Human |
| Specificity |
Recognizes human progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F. |
| Purity Detail | Protein A-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
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