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Detects mouse progranulin. Does not cross-react with human progranulin.
Crossreactivity
Mouse
Quantity
1 x 96 wells
2 x 96 wells (Twin Plex)
Sensitivity
60pg/ml
Range
0.125 to 8ng/ml
Sample Type
Cell Culture Supernatant Serum
Assay Type
Sandwich
Detection Type
Colorimetric
Shipping and Handling
Shipping
BLUE ICE
Short Term Storage
+4°C
Long Term Storage
+4°C
Handling Advice
After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use.
Use/Stability
12 months after the day of manufacturing. See expiry date on ELISA Kit box.
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD, but also for other types of Alzheimer‘s disease (AD). This new data even supposes the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Product References
Microglial upregulation of progranulin as a marker of motor neuron degeneration: T. Philips, et al.; J. Neuropathol. Exp. Neurol. 69, 1191 (2010) [CSF]
Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation: T. Nedachi, et al.; Neuroscience 185, 106 (2011)
The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function: O.A. Brady, et al.; Hum. Mol. Genet. 22, 685 (2013)
Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice: A.J. Filiano, et al.; J. Neurosci. 33, 5352 (2013) [Plasma, Brain Lysate]
Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice: Y. Yang, et al.; Lab. Invest. 94, 1224 (2014) [Plasma, Brain Lysate]
Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor B (RANK)-dependent formation of multinucleated osteoclasts: J. Oh, et al.; J. Biol. Chem. 290, 2042 (2015)
Effects of exercise on progranulin levels and gliosis in progranulin-insufficient mice: A.E. Arrant, et al.; eNeuro 2, e0061-14.2015 (2015) [Plasma, Brain Lysate]
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia: C.J. Holler, et al.; Mol. Neurodegener. 11, 46 (2016) [Plasma, Brain Lysate]
Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock: Y. Yu, et al.; J. cell Mol. Med. 20, 506 (2016)
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes: Y. Tanaka, et al.; Hum. Mol. Genet. 26, 969 (2017)
Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis: A.E. Arrant, et al.; J. Neurosci. 38, 2341 (2018) [Plasma, Brain Lysate]
Female-Specific Role of Progranulin to Suppress Bone Formation: L. Wang, et al.; Endocrinol. 160, 2024 (2019) [Serum]
Inter-Species Differences in Regulation of the Progranulin–Sortilin Axis in TDP-43 Cell Models of Neurodegeneration: V. Gumina, et al.; Int. J. Mol. Sci. 20, 5866 (2019)
Progranulin promotes immune evasion of pancreatic adenocarcinoma through regulation of MHCI expression: P.F. Cheung, et al.; Nature Commun. 13, 156 (2021)
Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice: J. Frew & H. Berge Nygaard; Acta Neuropathol. Commun. 9, 57 (2021)
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Progranulin (rat) ELISA Kit AG-45A-0043Y
Progranulin (human) ELISA Kit AG-45A-0018Y