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Inhibits the biosynthesis of cyclic peptide quormones in Gram-positive bacteria.
Lead compound for antipathogenic drugs that target the quorum-sensing-mediated virulence expression of Gram-positive bacteria.
Product References
Ambuic acid, a highly functionalized cyclohexenone with antifungal activity from Pestalotiopsis spp. and Monochaetia sp: J.Y. Li, et al.; Phytochemistry 56, 463 (2001)
Ambuic acid inhibits the biosynthesis of cyclic peptide quormones in gram-positive bacteria: J. Nakayama, et al.; Antimicrob. Agents Chemother. 53, 580 (2009)
Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp.: G. Ding, et al.; J. Nat. Prod. 72, 182 (2009)
Characterization of an Autoinducing Peptide Signal Reveals Highly Efficacious Synthetic Inhibitors and Activators of Quorum Sensing and Biofilm Formation in Listeria monocytogenes (2023): KHJ. West, et al.; Biochemistry 62, 2878 (2023)