Neobavaisoflavone

Specifications / Handling

More Information
Product Details
Synonyms	7-Hydroxy-3-(4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl)-4H-1-benzopyran-4-one; 3'-Prenyldaidzein
Product Type	Chemical
Properties
Formula	C₂₀H₁₈O₄
MW	322.4
CAS	41060-15-5
Source/Host Chemicals	Isolated from Psoralea corylifolia sp.
Purity Chemicals	≥98% (HPLC)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO, ethanol or methanol.
Identity	Determined by ¹H-NMR and MS.
InChi Key	OBGPEBYHGIUFBN-UHFFFAOYSA-N
Smiles	OC1=CC=C(C(C(C2=CC=C(O)C(C/C=C(C)/C)=C2)=CO3)=O)C3=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Antibiotic. Antibacterial and antifungal compound. Displays antibiotic activity against Gram-negative multidrug resistant bacteria.
Anticancer compound. DNA polymerase inhibitor. Enhances TRAIL-induced apoptosis via inhibition of metastasis.
Anti-inflammatory agent inhibiting IL-6-induced STAT3 activation and phosphorylation.
Platelet aggregation inhibitor.
Human carboxylesterase 1&2 and UDP-glucuronosyltransferase 1A1 inhibitor, enzymes important in drug metabolism.
Antioxidant. Inhibits the production of nitric oxide (NO), reactive oxygen species (ROS) and reactive nitrogen species (RNS).
Neuroprotective. Exerts protective effects against H₂O₂-induced neuronal cell damage.
Shows osteogenic acitivty.

Product References

Prenylated isoflavanone from the roots of Erythrina sigmoidea: A.E. Nkengfack, et al.; Phytochemistry 36, 1047 (1994)
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996)
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998)
Studies on the chemical constituents of Psoralea corylifolia L.: B. Ruan, et al.; J. Asian Nat. Prod. Res. 9, 41 (2007)
The combination of TRAIL and isoflavones enhances apoptosis in cancer cells: J. Bronikowska, et al.; Molecules 15, 2000 (2010)
Inhibition of inflammatory mediators by neobavaisoflavone in activated RAW264.7 macrophages: E. Szliszka, et al.; Molecules 16, 3701 (2011)
Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells: M.-J. Don, et al.; Phytomed. 19, 551, (2012)
Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation: S.W. Lee, et al.; Planta Med. 78, 903 (2012)
Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells: Y.J. Kim, et al.; Life Sci. 95, 101 (2014)
Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells: V. Kuete, et al.; Phytomed. 21, 682 (2014)
Antibacterial activity of nineteen selected natural products against multi-drug resistant Gram-negative phenotypes: A.T. Mbaveng, et al.; SpringerPus 4, 823 (2015)
Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2: Y.G. Li, et al.; Fitoterapia 101, 99 (2015)
Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi): X.X. Wang, et al.; Toxicol. Appl. Pharmacol. 289, 70 (2015)
Quantitative analysis of Psoralea corylifolia L. and its neuroprotective and anti-neuroinflammatory effects in HT22 hippocampal cells and BV-2 microglia: Y.J. Kim, et al.; Molecules 21, e2076 (2016)
Inhibition behavior of fructus psoraleae’s ingredients towards human carboxylesterase 1 (hCES1): D.X. Sun, et al.; Xenobiotica 46, 503 (2016)

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