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AdipoGen Life Sciences
6BIO
40
CHF
CHF 40.00
In stock
AG-CR1-0056-M0011 mgCHF 40.00
AG-CR1-0056-M0055 mgCHF 90.00
AG-CR1-0056-M02525 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | (2’Z,3’E)-6-Bromoindirubin-3’-oxime |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H10BrN3O2 |
| MW | 356.2 |
| CAS | 667463-62-9 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Dark red solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | DDLZLOKCJHBUHD-WAVHTBQISA-N |
| Smiles | O\N=C1\C(\NC2=CC=CC=C\12)=C1\C(=O)NC2=C1C=CC(Br)=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Phosphoinositide-dependent kinase 1 (PDK1) inhibitor.
- Potent, reversible and ATP-competitive glycogen synthase kinase-3α/β (GSK-3α/β) inhibitor.
- JAK/STAT3 signaling inhibitor.
- Apoptosis inducer.
- Potent antiproliferative agent in malignant lymphoid cell.
- Antimetastatic agent.
- Potent chemosensitizing agent fighting TRAIL resistant cancer cells.
Product References
- GSK-3-selective inhibitors derived from Tyrian purple indirubins: L. Meijer, et al.; Chem. Biol. 10, 1255 (2003)
- Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004)
- The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes: A.S. Tseng, et al.; Chem. Biol. 13, 957 (2006)
- 7-Bromoindirubin-3'-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006)
- Inverse in silico screening for identification of kinase inhibitor targets: S. Zahler, et al.; Chem. Biol. 14, 1207 (2007)
- An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007)
- Indirubin derivatives inhibit malignant lymphoid cell proliferation: A. Chebel, et al.; Leuk. Lymphoma 50, 2049 (2009)
- 6-Bromoindirubin-3'-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells: L. Liu, et al.; Cancer Res. 71, 3972 (2011)
- Indirubin derivative 6BIO suppresses metastasis: S. Braig, et al.; Cancer Res. 73, 6004 (2013)
- The pleiotropic profile of the indirubin derivative 6BIO overcomes TRAIL resistance in cancer: S. Braig, et al.; Biochem. Pharmacol. 91, 157 (2014)
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