Me7BIO

CHF 120.00
In stock
AG-MR-C0022-M0055 mgCHF 120.00
AG-MR-C0022-M02525 mgCHF 310.00
More Information
Product Details
Synonyms 1-Methyl-7-bromo-indirubin-3'-oxime
Product Type Chemical
Properties
Formula

C17H12BrN3O2

MW 370.2
CAS 916440-98-7
Purity Chemicals ≥95% (NMR)
Appearance Dark red solid.
Solubility Soluble in DMSO or ethanol.
Reconstitution Stock solutions can be made up to 10mM in DMSO.
Identity Determined by 1H-NMR.
InChi Key KUNCCRCBMOXXLE-WAVHTBQISA-N
Smiles CN1C(=O)\C(=C2/NC3=CC=CC=C3/C/2=N\O)C2=C1C(Br)=CC=C2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • N-methylated inactive control compound for 7BIO (Prod. No. MR-C0020).
  • Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
Product References
  1. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the anti-proliferative effects of indirubins: M. Knockaert, et al.; Oncogene 23, 4400 (2004)
  2. Indirubin, the red shade of indigo: L. Meijer, et al. (Editors): In «Life in Progress», Station Biologique, Roscoff, 297 pp. (2006)
  3. 7-Bromoindirubin-3'-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006)
  4. An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007)
  5. Cutting edge: Necrosis activates the NLRP3 inflammasome: H. Li, et al.; J. Immunol. 183, 1528 (2009)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.