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AdipoGen Life Sciences
Me7BIO
120
CHF
CHF 120.00
In stock
AG-MR-C0022-M0055 mgCHF 120.00
AG-MR-C0022-M02525 mgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | 1-Methyl-7-bromo-indirubin-3'-oxime |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H12BrN3O2 |
| MW | 370.2 |
| CAS | 916440-98-7 |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | Dark red solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Reconstitution | Stock solutions can be made up to 10mM in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | KUNCCRCBMOXXLE-WAVHTBQISA-N |
| Smiles | CN1C(=O)\C(=C2/NC3=CC=CC=C3/C/2=N\O)C2=C1C(Br)=CC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- N-methylated inactive control compound for 7BIO (Prod. No. MR-C0020).
- Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
Product References
- Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the anti-proliferative effects of indirubins: M. Knockaert, et al.; Oncogene 23, 4400 (2004)
- Indirubin, the red shade of indigo: L. Meijer, et al. (Editors): In «Life in Progress», Station Biologique, Roscoff, 297 pp. (2006)
- 7-Bromoindirubin-3'-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006)
- An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007)
- Cutting edge: Necrosis activates the NLRP3 inflammasome: H. Li, et al.; J. Immunol. 183, 1528 (2009)
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