AdipoGen Life Sciences

6BIO

Name: 6BIO
Brand: AdipoGen Life Sciences
SKU: AG-MR-C0019
Price: 160.00 CHF
Availability: InStock

As low as CHF 160.00

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AG-MR-C0019-M01010 mgCHF 160.00

AG-MR-C0019-M05050 mgCHF 640.00

Specifications / Handling

More Information
Product Details
Synonyms	BIO; 6-Bromoindirubin-3'-oxime
Product Type	Chemical
Properties
Formula	C₁₆H₁₀BrN₃O₂
MW	356.2
CAS	667463-62-9
Purity Chemicals	≥99% (NMR)
Appearance	Dark red solid.
Solubility	Soluble in DMSO or ethanol.
Reconstitution	Stock solutions can be made up to 10mM in DMSO.
Identity	Determined by ¹H-NMR.
InChi Key	DDLZLOKCJHBUHD-WAVHTBQISA-N
Smiles	O\N=C1\C(\NC2=CC=CC=C\12)=C1\C(=O)NC2=C1C=CC(Br)=C2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Potent, reversible and ATP-competitive glycogen synthase kinase-3α/β (GSK-3α/β) inhibitor.
JAK/STAT3 signaling inhibitor.
Phosphoinositide-dependent kinase 1 (PDK1) inhibitor.
Anticancer compound.
Potent antiproliferative agent. Suppresses metastasis.
Apoptosis inducer.
Sustains pluripotency and self-renewal of human and mouse embryonic stem cells (ESCs) by activation of the Wnt signaling pathway.
Anti-leishmanial (IC₅₀ = 0.150μM).
Proto-oncogene tyrosine-protein kinase receptor RET inhibitor (IC₅₀=0.51μM).
Inhibits HIV-1 transcription and protects against Tat induced neurotoxicity.

Product-specific References

GSK-3-selective inhibitors derived from Tyrian purple indirubins: L. Meijer, et al.; Chem. Biol. 10, 1255 (2003)
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004)
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor: N. Sato, et al.; Nat. Med. 10, 55 (2004)
The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes: A.S. Tseng, et al.; Chem. Biol. 13, 957 (2006)
7-Bromoindirubin-3'-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006)
Indirubin, the red shade of indigo: L. Meijer, et al. (Editors): In «Life in Progress», Station Biologique, Roscoff, 297 pp. (2006)
Indirubin derivatives inhibit malignant lymphoid cell proliferation: A. Chebel, et al.; Leuk. Lymphoma 50, 2049 (2009)
6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: Exploitation of GSK-3 for treating leishmaniasis: E. Xingi, et al.; Int. J. Parasit. 39, 1289 (2009)
Anticancer effects and antimetastatic mechanisms of novel indirubin derivatives: C.A. Kressirer; Diss. Ludwig-Maximilians-Universitaet Munchen, (2010)
6-Bromoindirubin-3'-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells: L. Liu, et al.; Cancer Res. 71, 3972 (2011)
Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors: K. Kehn-Hall, et al.; Virology 415, 56 (2011)
Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells: K.A. Nicolaou, et al.; BBRC 425, 76 (2012)
From Tyrian purple to kinase modulators: naturally halogenated indirubins and synthetic analogues: K. Vougogiannopoulou & A.L. Skaltsounis; Planta Med. 78, 1518 (2012)
Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells: C.R. McClain, et al.; J. Neurosci. 32, 15066 (2012)
Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK kinases: V. Myrianthopoulos, et al.; ACS Med. Chem. Lett 4, 22 (2013)
Indirubin Derivative 6BIO Suppresses Metastasis: S. Braig, et al.; Cancer Res. 73, 6004 (2013)

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