Me6BIO

CHF 130.00
In stock
AG-MR-C0021-M0055 mgCHF 130.00
AG-MR-C0021-M02525 mgCHF 520.00
More Information
Product Details
Synonyms MeBIO; 1-Methyl-6-bromo-indirubin-3'-oxime
Product Type Chemical
Properties
Formula

C17H12BrN3O2

MW 370.2
CAS 667463-95-8
Purity Chemicals ≥95% (NMR)
Appearance Dark red solid.
Solubility Soluble in DMSO or ethanol.
Reconstitution Stock solutions can be made up to 10mM in DMSO.
Identity Determined by 1H-NMR.
InChi Key JUKQKURGZYNHFN-NVVUQHMZSA-N
Smiles CN1C(=O)\C(=C2/NC3=CC=CC=C3/C/2=N\O)C2=C1C=C(Br)C=C2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • N-methylated inactive control analog of 6-bromoindirubin-3'-oxime (6BIO) (Prod. No. MR-C0019).
  • Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β and CDK5/p25.
  • Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
Product References
  1. GSK-3-selective inhibitors derived from Tyrian purple indirubins: L. Meijer, et al.; Chem. Biol. 10, 1255 (2003)
  2. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004)
  3. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins: M. Knockaert, et al.; Oncogene 23, 4400 (2004)
  4. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes: A.S. Tseng, et al.; Chem. Biol. 13, 957 (2006)
  5. Indirubin, the red shade of indigo: L. Meijer, et al. (Editors): In «Life in Progress», Station Biologique, Roscoff, 297 pp. (2006)
  6. Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments: S.P. Williams, et al.; Cancer Res. 71, 5374 (2011)
  7. Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells: C.R. McClain, et al.; J. Neurosci. 32, 15066 (2012)
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