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AdipoGen Life Sciences
Me6BIO
130
CHF
CHF 130.00
In stock
AG-MR-C0021-M0055 mgCHF 130.00
AG-MR-C0021-M02525 mgCHF 520.00
| Product Details | |
|---|---|
| Synonyms | MeBIO; 1-Methyl-6-bromo-indirubin-3'-oxime |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H12BrN3O2 |
| MW | 370.2 |
| CAS | 667463-95-8 |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | Dark red solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Reconstitution | Stock solutions can be made up to 10mM in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | JUKQKURGZYNHFN-NVVUQHMZSA-N |
| Smiles | CN1C(=O)\C(=C2/NC3=CC=CC=C3/C/2=N\O)C2=C1C=C(Br)C=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- N-methylated inactive control analog of 6-bromoindirubin-3'-oxime (6BIO) (Prod. No. MR-C0019).
- Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β and CDK5/p25.
- Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
Product References
- GSK-3-selective inhibitors derived from Tyrian purple indirubins: L. Meijer, et al.; Chem. Biol. 10, 1255 (2003)
- Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004)
- Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins: M. Knockaert, et al.; Oncogene 23, 4400 (2004)
- The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes: A.S. Tseng, et al.; Chem. Biol. 13, 957 (2006)
- Indirubin, the red shade of indigo: L. Meijer, et al. (Editors): In «Life in Progress», Station Biologique, Roscoff, 297 pp. (2006)
- Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments: S.P. Williams, et al.; Cancer Res. 71, 5374 (2011)
- Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells: C.R. McClain, et al.; J. Neurosci. 32, 15066 (2012)
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