C646 | CAS 328968-36-1 - Order from Adipogen

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Product Details
Synonyms	(E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Product Type	Chemical
Properties
Formula	C₂₄H₁₉N₃O₆
MW	445.4
CAS	328968-36-1
Purity Chemicals	≥98% (NMR)
Appearance	Red solid.
Solubility	Soluble in DMSO (10mg/ml).
Identity	Determined by ¹H-NMR. Mixture of isomers E/Z ~ 4:1.
InChi Key	HEKJYZZSCQBJGB-XDHOZWIPSA-N
Smiles	CC1=NN(C(=O)\C1=C\C1=CC=C(O1)C1=CC(C)=C(C)C=C1[N+]([O-])=O)C1=CC=C(C=C1)C(O)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep under inert gas. Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor.
Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%).
Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines.

Product References

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor: E.M. Bowers, et al.; Chem. Biol. 17, 471 (2010)
HAT Trick: p300, Small Molecule, Inhibitor: M. Ott & E. Verdin; Chem. Biol. 17, 417 (2010)
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetics remodeling and the expression of pluripotency-associated genes: P. Mali, et al.; Stem Cells 28, 713 (2010)
Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP: N.T. Crump, et al.; PNAS 108, 7814 (2011)
Paradoxical Enhancement of Fear Extinction Memory and Synaptic Plasticity by Inhibition of the Histone Acetyltransferase p300: R. Marek, et al.; J. Neurosci. 31, 7486 (2011)
Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines: F.R. Santer, et al.; Mol. Cancer Ther. 10, 1644 (2011)
Histone-deacetylase-inhibitory effects of periodontopathic-bacterial metabolites induce human gingival epithelial Ca9-22 cell death: K. Uemichi, et al.; Odontology ahead of print (2022)

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