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AdipoGen Life Sciences
Anacardic acid
65
CHF
CHF 65.00
In stock
AG-CR1-0046-M0055 mgCHF 65.00
AG-CR1-0046-M02525 mgCHF 220.00
| Product Details | |
|---|---|
| Synonyms | 2-Hydroxy-6-pentadecylbenzoic acid; 6-Pentadecylsalicylic acid; AA |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H36O3 |
| MW | 348.5 |
| Merck Index | 14: 621 |
| CAS | 16611-84-0 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate. |
| Other Product Data |
Stock solutions are stable for up to 3 months when stored at -20°C. |
| InChi Key | ADFWQBGTDJIESE-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCCCCCC1=CC=CC(O)=C1C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent histone acetyltransferase (HAT) inhibitor [1, 2].
- Antibacterial [3].
- SUMOylation inhibitor [4].
- Lipoxygenase inhibitor [5].
- NF-κB inhibitor [6].
- Anti-tumor compound [2, 6-8].
- Anti-inflammatory [6].
- Apoptosis inducer [6, 7].
- Antiproliferative [7].
Product References
- Small molecule modulators of histone acetyltransferase p300: K. Balasubramanyam, et al.; J. Biol. Chem. 278, 19134 (2003)
- Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation: Y. Sun, et al.; FEBS Lett. 580, 4353 (2006)
- Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi & I. Kubo; J. Appl. Bacteriol. 80, 387 (1996)
- Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate: I. Fukuda, et al.; Chem. Biol. 16, 133 (2009)
- Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids: R. Grazzini, et al.; BBRC 176, 775 (1991)
- Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis: B. Sung, et al.; Blood 111, 4880 (2008)
- Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells: S. Sukumari-Ramesh, et al.; J. Neurosurg. 114, 1681 (2011)
- Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation: D.J. Schultz, et al.; Mol. Cancer Ther. 9, 594 (2010)
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