AdipoGen Life Sciences

Butyrolactone 3

CHF 130.00
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AG-CR1-3522-M0022 mgCHF 130.00
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Product Details
Synonyms (2R,3S)-rel-Tetrahydro-4-methylene-5-oxo-2-propyl-3-furancarboxylic acid; MB-3
Product Type Chemical


MW 184.2
CAS 778649-18-6
Source/Host Chemicals Synthetic
Purity Chemicals ≥95% (NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO or methanol.
Identity Determined by 1H-NMR.
Smiles CCC[C@@H]1OC(=O)C(=C)[C@H]1C(O)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Specific histone acetyltransferase Gcn5 inhibitor [1, 2].
  • Anticancer compound [2, 4].
  • Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps [3].
  • Potential anti-inflammatory compound.
Product References
  1. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5: M. Biel, et al.; Angew. Chem. Int. Ed. Engl. 43, 3974 (2004)
  2. Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties: A. Mai, et al.; J. Med. Chem. 49, 6897 (2006)
  3. Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation: A.N. Kuhn, et al.; RNA 15, 153 (2009)
  4. GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia: T. Holmlund, et al.; Leukemia 27, 578 (2013)
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