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AdipoGen Life Sciences
Butyrolactone 3
130
CHF
CHF 130.00
In stock
AG-CR1-3522-M0022 mgCHF 130.00
| Product Details | |
|---|---|
| Synonyms | (2R,3S)-rel-Tetrahydro-4-methylene-5-oxo-2-propyl-3-furancarboxylic acid; MB-3 |
| Product Type | Chemical |
| Properties | |
| Formula |
C9H12O4 |
| MW | 184.2 |
| CAS | 778649-18-6 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | SRQUTZJZABSZRQ-NKWVEPMBSA-N |
| Smiles | CCC[C@@H]1OC(=O)C(=C)[C@H]1C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Specific histone acetyltransferase Gcn5 inhibitor [1, 2].
- Anticancer compound [2, 4].
- Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps [3].
- Potential anti-inflammatory compound.
Product References
- Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5: M. Biel, et al.; Angew. Chem. Int. Ed. Engl. 43, 3974 (2004)
- Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties: A. Mai, et al.; J. Med. Chem. 49, 6897 (2006)
- Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation: A.N. Kuhn, et al.; RNA 15, 153 (2009)
- GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia: T. Holmlund, et al.; Leukemia 27, 578 (2013)
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