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AdipoGen Life Sciences
GCN5 (human) (rec.) (His) (highly active)
280
CHF
CHF 280.00
In stock
AG-40T-0017-C0022 µgCHF 280.00
| Product Details | |
|---|---|
| Synonyms | GCN5L2; Histone Acetyltransferase GCN5; Histone Acetyltransferase KAT2A; Lysine Acetyltransferase 2A; STAF97 |
| Product Type | Protein |
| Properties | |
| Source/Host | Sf21 cells |
| Sequence | Human GCN5 is fused to a His-tag. |
| Crossreactivity | Human |
| Biological Activity | ~200-300ng are required for standard HAT assay. |
| Purity | ≥95% (SDS-PAGE) |
| Concentration | Lot dependent (0.2-0.5mg/ml) |
| Formulation | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol. |
| Other Product Data | UniProt ID Q92830: GCN5 (human) |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice |
After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -80°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. It has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. It regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. GCN5 is a component of the Ada Two-A containing (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Product References
- Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65: C. Buerki, et al.; Nucleic Acids Res. 36, 1665 (2008)
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