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AdipoGen Life Sciences
CREB-binding Protein (mouse) (rec.) (His) (highly active)
290
CHF
CHF 290.00
In stock
AG-40T-0016-C0022 µgCHF 290.00
| Product Details | |
|---|---|
| Synonyms | CBP; CREBBP |
| Product Type | Protein |
| Properties | |
| Source/Host | Sf21 cells |
| Sequence | Mouse full-length CREB-binding protein fused at the C-terminus to a His-tag. |
| Crossreactivity | Mouse |
| Biological Activity | ~50-100ng are required for standard HAT assay. |
| Purity | ≥95% (SDS-PAGE) |
| Concentration | Lot dependent (0.2-0.5mg/ml) |
| Formulation | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol. |
| Other Product Data | UniProt ID P45481: CREB Binding Protein (mouse) |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice |
After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -80°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
CREB-binding protein acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
Product References
- Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65: C. Buerki, et al.; Nucleic Acids Res. 36, 1665 (2008)
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