Butyrolactone 3

More Information
Product Details
Synonyms	(2R,3S)-rel-Tetrahydro-4-methylene-5-oxo-2-propyl-3-furancarboxylic acid; MB-3
Product Type	Chemical
Properties
Formula	C₉H₁₂O₄
MW	184.2
CAS	778649-18-6
Source/Host Chemicals	Synthetic
Purity Chemicals	≥95% (NMR)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO or methanol.
Identity	Determined by ¹H-NMR.
InChi Key	SRQUTZJZABSZRQ-NKWVEPMBSA-N
Smiles	CCC[C@@H]1OC(=O)C(=C)[C@H]1C(O)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Specific histone acetyltransferase Gcn5 inhibitor [1, 2].
Anticancer compound [2, 4].
Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps [3].
Potential anti-inflammatory compound.

Product References

Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5: M. Biel, et al.; Angew. Chem. Int. Ed. Engl. 43, 3974 (2004)
Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties: A. Mai, et al.; J. Med. Chem. 49, 6897 (2006)
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation: A.N. Kuhn, et al.; RNA 15, 153 (2009)
GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia: T. Holmlund, et al.; Leukemia 27, 578 (2013)

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