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BioViotica
3,28-Di-O-(3,3-dimethylglutaryl)betulin
115
CHF
CHF 115.00
In stock
BVT-0404-M0011 mgCHF 115.00
BVT-0404-M0055 mgCHF 340.00
| Product Details | |
|---|---|
| Synonyms | 3,28-di(diMeG)betulin; NSC705961; Betulin 3,28-(3,3-dimethyl)glutarate |
| Product Type | Chemical |
| Properties | |
| Formula |
C44H70O8 |
| MW | 727.0 |
| Source/Host Chemicals | Semi-synthetic derivative from betulin (from birch bark). |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white solid. This substance is hygroscopic and might gradually change its state of aggregation from solid to oil. |
| Solubility | Soluble in methanol, acetone or DMSO. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | MPCSQAWQRMXLDD-GVCIVQAHBD |
| Smiles | [H][C@]12[C@@H](CCC1(COC(=O)CC(C)(C)CC(O)=O)CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CC(C)(C)CC(O)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(C)=C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Very hygroscopic. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Semi-synthetic derivative of betulin (from birch bark).
- Potent antiviral compound.
- Shows anti-HIV activity (more active than AZT in vitro).
Product References
- Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives: I.-C. Sun, et al.; Bioorg. Med. Chem. Lett. 8, 1267 (1998)
- Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents: I.-C. Sun, et al.; J. Med. Chem. 41, 4648 (1998)
- 3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents: Y. Kashiwada, et al.; Bioorg. Med. Chem. Lett. 11, 183 (2001)
- 3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents: Y. Kashiwada, et al.; Bioorg. Med. Chem. Lett. 14, 5851 (2004)
- Birch bark research and development: P.A. Krasutsky; Nat. Prod. Rep. 23, 919 (2006)
- Pharmacological properties of the ubiquitous natural product betulin: S. Alakurtti, et al.; Eur. Pharm. Sci. 29, 1 (2006)
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