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BioViotica
5-Methylmellein
85
CHF
CHF 85.00
In stock
BVT-0413-M0011 mgCHF 85.00
| Product Details | |
|---|---|
| Synonyms | 5- Methylochracin; 3,4-Dihydro-8-hydroxy-3,5-dimethyl-1H-2-benzopyran1- one; 3,4-Dihydro-8-hydroxy-3,5-dimethylisocoumarin |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H12O3 |
| MW | 192.2 |
| CAS | 7734-92-1 |
| Source/Host Chemicals | Isolated from Fusicoccum amygdalis. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Pale yellow powder. |
| Solubility | Soluble in DMSO, chloroform or dichloromethane. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | YETSBBYQOFXYGV-SSDOTTSWSA-N |
| Smiles | C[C@@H]1CC2=C(C(O)=CC=C2C)C(=O)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Widespread fungal pentaketide.
- Weak antibacterial, antifungal and antiviral activity.
- Specific inhibitor of human DNA polymerase λ.
- Weak antigerminative activity.
Product References
- 5-Methylmellein, a new natural dihydroisocoumarin: A. Ballio, et al.; Tetrahedron Lett. 1966, 3723 (1966)
- (-)-5-Methylmellein and catechol derivatives from four semecarpus species: R.C. Carpenter, et al.; Phytochemistry 19, 445 (1980)
- 3-Methyl-3,4-dihydroisocoumarins and related compounds from the ascomycete family xylariaceae: J.R. Anderson & R.L. Edwards; J. Chem. Soc. Perkin Trans I 1983, 2185 (1983)
- Dihydroisocoumarins from fungi: isolation, structure elucidation, circular dichroism and biological activity: K. Krohn, et al.; Phytochemistry 45, 313 (1997)
- Nodulisporol and nodulisporone, novel specific inhibitors of human DNA polymerase λ from a fungus, Nodulisporium sp.: S. Kamisuki, et al.; Bioorg. Med. Chem. 15, 3109 (2007)
- Bioactive aromatic derivatives from endophytic fungus, Cytospora sp.: S. Lu, et al.; Nat. Prod. Commun. 6, 661 (2011)
- Guaiane sesquiterpenes from Biscogniauxia nummularia featuring potent antigerminative activity: S. Amand, et al.; J. Nat. Prod. 75, 798 (2012)
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