Chemodex

ZnAF-1F

CHF 150.00

In stock

CDX-Z0009-M0011 mgCHF 150.00

CDX-Z0009-M0055 mgCHF 584.00

CDX-Z0009-M02525 mgCHF 1'561.00

More Information
Product Details
Synonyms	5-{2-[Bis(2-pyridylmethyl)amino]ethylamino}-2′,7′-difluorofluorescein
Product Type	Chemical
Properties
Formula	C₃₄H₂₆F₂N₄O₅
MW	608.59
CAS	443302-08-7
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥90% (HPCE)
Appearance	Dark red powder.
Solubility	Soluble in DMSO.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	VRUAOMSCYBFMTB-UHFFFAOYSA-N
Smiles	OC1=CC2=C(C=C1F)C1(OC(=O)C3=C1C=CC(NCCN(CC1=CC=CC=N1)CC1=NC=CC=C1)=C3)C1=CC(F)=C(O)C=C1O2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

ZnAF-1F and ZnAF-2F do not fluoresce in the presence of other biologically important cations such as Ca2+ and Mg2+, and are insensitive to change of pH. The complexes with Zn2+ of previously developed ZnAFs, ZnAF-1, and ZnAF-2 decrease in fluorescence intensity below pH 7.0 owing to protonation of the phenolic hydroxyl group of fluorescein, whose pKa value is 6.2. On the other hand, the Zn2+ complexes of ZnAF-1F and ZnAF-2F emit stable fluorescence under neutral and slightly acidic conditions because the pKa values are shifted to 4.9 by substitution of electron-withdrawing fluorine at the ortho position of the phenolic hydroxyl group. Spectral data: λex 492nm; λem 517nm in PBS.

Product References

(1) T. Hirano et al. JACS 124, 6555 (2002)

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