AdipoGen Life Sciences

anti-BAFF (human), mAb (blocking) (4.62) (Biotin)

CHF 490.00

In stock

AG-20B-0017B-C100100 µgCHF 490.00

More Information
Product Details
Synonyms	BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B
Product Type	Monoclonal Antibody
Properties
Clone	4.62
Isotype	Rat IgG2a
Source/Host	Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen	HA-tagged human BAFF.
Label/Conjugates	Biotin
Application	ELISA Functional Application: Inhibition of human BAFF binding. Immunoprecipitation: (1:200)
Crossreactivity	Human
Specificity	Recognizes human BAFF.
Purity	≥95% (SDS-PAGE)
Purity Detail	Protein G-affinity purified.
Concentration	0.5mg/ml
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).

Product References

Kinetics of free and ligand-bound atacicept in human serum: M. Eslami, et al.; Front. Immunol. 13, 1035556 (2022)

Call	+41 61 926 6040
Fax	+41 61 926 6049