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AdipoGen Life Sciences
anti-BAFF-R (mouse), mAb (9B9) (preservative free)
410
CHF
CHF 410.00
In stock
AG-20B-0034PF-C100100 µgCHF 410.00
| Product Details | |
|---|---|
| Synonyms | BAFF Receptor; BR3; BlySR3; CD268; TNFRSF13C |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 9B9 |
| Isotype | Rat IgG2b |
| Source/Host | Purified from concentrated hybridoma tissue culture supernatant. |
| Immunogen/Antigen | Y3 cells transfected with mouse BAFF-R. |
| Application |
Flow Cytometry Functional Application: Depletion of B cells in vivo. Optimal conditions must be determined individually for each application. |
| Crossreactivity | Mouse |
| Specificity | Recognizes mouse BAFF-R. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein G-affinity purified. |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test; Lonza). |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF-R signaling is essential for B cell development, survival and humoral immune responses.
Product References
- Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells: M. Rauch, et al.; PLoS ONE 4, e5456 (2009)
- BAFF-R expression correlates with positive selection of immature B cells: R. Tussiwand, et al.; Eur. J. Immunol. 42, 206 (2012)
- PD-L1hi B cells are critical regulators of humoral immunity: A.R. Khan, et al.; Nat. Commun. 6, 5997 (2015)
- The unknown aspect of BAFF: Inducing IL-35 production by a CD5+CD1dhiFcγRIIbhi regulatory B-Cell subset in lupus: Y. Zhang, et al.; J. Invest. Dermatol. 137, 2532 (2017)
- B-1a lymphocytes promote oligodendrogenesis during brain development: S. Tanabe & T. Yamashita; Nature Neurosci. 21, 506 (2018)
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