Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
(S)-CR8
70
CHF
CHF 70.00
In stock
AG-CR1-0040-M0011 mgCHF 70.00
AG-CR1-0040-M0055 mgCHF 200.00
| Product Details | |
|---|---|
| Synonyms | 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H29N7O |
| MW | 431.5 |
| CAS | 1084893-56-0 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or 100% ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | HOCBJBNQIQQQGT-IBGZPJMESA-N |
| Smiles | CC[C@@H](CO)NC1=NC2=C(N=CN2C(C)C)C(NCC2=CC=C(C=C2)C2=NC=CC=C2)=N1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor [1].
- Apoptosis inducer [1, 2].
- Glycogen synthase kinase (GSK-3α/β) inhibitor [1].
Product References
- CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008)
- CDK inhibitors roscovitine and CR8 trigger Mcl-1 down-regulation and apoptotic cell death in neuroblastoma cells: K. Bettayeb, et al.; Genes Cancer 1, 369 (2010)
- CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD: N.O. Bukanov, et al.; Cell Cycle 11, 4040 (2012)
- Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice: H. Sallam, et al.; BMC Pharmacol. Toxicol. 14, 50 (2013)
- Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)
- Systemic Administration of the Cyclin‐Dependent Kinase Inhibitor (S)‐CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats: S.P. Goulding, et al.; Alcohol Clin. Exp. Res. 43, 2079 (2019)
Related Products
