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AdipoGen Life Sciences
(R)-CR8
70
CHF
CHF 70.00
In stock
AG-CR1-0039-M0011 mgCHF 70.00
AG-CR1-0039-M0055 mgCHF 200.00
| Product Details | |
|---|---|
| Synonyms | 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H29N7O |
| MW | 431.5 |
| CAS | 294646-77-8 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or 100% ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | HOCBJBNQIQQQGT-LJQANCHMSA-N |
| Smiles | CC[C@H](CO)NC1=NC2=C(N=CN2C(C)C)C(NCC2=CC=C(C=C2)C2=NC=CC=C2)=N1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor [1].
- Apoptosis inducer [1].
- Potent glycogen synthase kinase (GSK-3α/β) inhibitor [1].
Product References
- CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008)
- Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice: H. Sallam, et al.; BMC Pharmacol. Toxicol. 14, 50 (2013)
- Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)
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