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BioViotica
Chaetoglobosin A
90
CHF
CHF 90.00
In stock
BVT-0092-M0011 mgCHF 90.00
BVT-0092-M0055 mgCHF 335.00
| Product Details | |
|---|---|
| Synonyms | NSC366739; BRN1097707 |
| Product Type | Chemical |
| Properties | |
| Formula |
C32H36N2O5 |
| MW | 528.7 |
| CAS | 50335-03-0 |
| Source/Host Chemicals | Isolated from Chaetomium sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in methanol; almost insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | OUMWCYMRLMEZJH-HSXMBTRQSA-N |
| Smiles | [H][C@]12[C@H](CC3=CNC4=CC=CC=C34)NC(=O)[C@@]11C(=O)\C=C\C(=O)[C@H](O)\C(C)=C/[C@@H](C)C\C=C\[C@]1([H])[C@@H]1O[C@]1(C)[C@H]2C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- Cytochalasan analog with anti-fungal activity.
- Phytotoxic, nematicidal and anti-bacterial activity.
- Exhibits cytotoxic effects against human cancer cell lines.
- Induces apoptosis in lymphocytic leukemia cells by targeting the cytoskeleton.
- Enhances fibrinolytic activity of bovine aortic endothelial cells.
- Mycotoxin.
Product References
- Acute toxic effects of chaetoglobosin A, a new cytochalasan compound produced by Chaetomium globosum, on mice and rats: K. Ohtsubo, et al.; Jpn. J. Exp. Med. 48, 105 (1978)
- Chaetoglobosins, cytotoxic 10-(indol-3-yl)-[13]cytochalasans from Chaetomium spp. I. Production, isolation and some cytological effects of chaetoglobosins A-J: S. Sekita, et al.; Chem. Pharm. Bull. 30, 1609 (1982)
- Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B: C. Shinohara, et al.; J. Antibiot. 53, 262 (2000)
- Phytotoxic chaetoglobosins are produced by the plant pathogen Calonectriam organii (anamorph Cylindrocladium scoparium): C. Von Wallbrunn, et al.; J. Gen. Appl. Microbiol. 47, 33 (2001)
- Chaetoglobosins Q, R, and T, three further new metabolites from Chaetomium globosum: W. Jiao, et al.; J. Nat. Prod. 67, 1722 (2004)
- Growth and mycotoxin production by Chaetomium globosum: M.R. Fogle, et al.; Mycopathologia 164, 49 (2007)
- New azaphilones from Chaetomium globosum isolated from the built environment: D. R. McMullin, et al.; Tetrahedron Lett. 54, 568 (2013)
- Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis: K. Ishiuchi, et al.; JACS 135, 7371 (2013)
- Nematicidal activity of chaetoglobosin A produced by Chaetomium globosum NK102 against Meloidogyne incognita: Y. Hu, et al.; J. Agricult. Food Chem. 61, 41 (2013)
- Efficacy assessment of antifungal metabolites from Chaetomium globosum No.05, a new biocontrol agent, against Setosphaeria turcica: G. Zhang, et al.; BioControl 64, 90 (2013)
- Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton: P. B. Knudson, et al.; Leukemia 28, 1289 (2014)
- Production of vineomycin A1 and chaetoglobosin A by Streptomyces sp. PAL114: A. Aouiche, et al.; Ann. Microbiol. 65, 1351 (2015)
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