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Chemodex
TFMU
95
CHF
CHF 95.00
In stock
CDX-T0003-G0011 gCHF 95.00
CDX-T0003-GG252.5 gCHF 189.00
| Product Details | |
|---|---|
| Synonyms | 4-(Trifluoromethyl)umbelliferone |
| Product Type | Chemical |
| Properties | |
| Formula | C10H5F3O3 |
| MW | 230.14 |
| CAS | 575-03-1 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white crystalline powder. |
| Solubility | Soluble in alcohols, DMSO or DMF. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | CCKWMCUOHJAVOL-UHFFFAOYSA-N |
| Smiles | OC1=CC=C2C(OC(=O)C=C2C(F)(F)F)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
This compound is widely used as a substrate for Cytochrome P450. It has also been used as a marker substrate for assessment of Drug-Drug interactions to multiple isoforms of UDP-glucuronosyltransferases. Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.
Product References
(1) P. Baranczewski; Assay and Drug Developm. Techn. 2(4), 345 (2004) | (2) A.B. Renwick; Xenobiotica 30(10), 955 (2000) | (3) G. Luyten et al.; J. Histochem. Cytochem. 33, 965 (1985)
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