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Chemodex
7-Methoxy-4-(trifluoromethyl)coumarin
156
CHF
CHF 156.00
In stock
CDX-M0015-M05050 mgCHF 156.00
CDX-M0015-M250250 mgCHF 659.00
| Product Details | |
|---|---|
| Synonyms | MFC; Methyl 4-(trifluoromethyl)umbelliferyl ether |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H7F3O3 |
| MW | 244.17 |
| CAS | 575-04-2 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥99% (TLC) |
| Appearance | White powder. |
| Solubility | Soluble in ethanol, methanol, DMSO or DMF. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HAZHUELNIGDYQH-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Fluorescent substrate for oxidoreductases, especially for Cytochrome P450 family members CYP2C9, CYP2C19, and CYP2E1. Spectral data: λex=333nm; λem=416nm (in methanol). Has been used extensively in high-throughput screens in fluorometric p450 activity assays, and is metabolized to the fluorescent metabolite 7-Hydroxy-4-trifluoromethylcoumarin (HFC) with λex=410nm; λem=538nm.
Product References
(1) M. Matsui, et al.; Chem. Ber. 125, 467 (1992) | (2) D.M. Stresser, et al.; Drug Metab. Dispos. 30, 845 (2002) | (3) A.Ghosal, et al.; Biopharm. Drug Dispos. 24, 375 (2003) | (4) M.T. Donato, et al.; Drug Metabol. Dispos. 32, 699 (2004) | (5) M.A. Hummel, et al.; J. Biomol. Scr. 11, 303 (2006) | (6) D. Jacquemin, et al.; J. Chem. Phys. 125, 164324 (2006) | (7) I. Kaminska, et al.; Polymer Test. 55, 310 (2016)
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