7-Methoxy-4-(trifluoromethyl)coumarin

CHF 147.00
In stock
CDX-M0015-M05050 mgCHF 147.00
CDX-M0015-M250250 mgCHF 619.00
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Product Details
Synonyms MFC; Methyl 4-(trifluoromethyl)umbelliferyl ether
Product Type Chemical
Properties
Formula

C11H7F3O3

MW 244.17
CAS 575-04-2
Source/Host Chemicals Synthetic.
Purity Chemicals ≥99% (TLC)
Appearance White powder.
Solubility Soluble in ethanol, methanol, DMSO or DMF.
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key HAZHUELNIGDYQH-UHFFFAOYSA-N
Smiles COC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Fluorescent substrate for oxidoreductases, especially for Cytochrome P450 family members CYP2C9, CYP2C19, and CYP2E1. Spectral data: λex=333nm; λem=416nm (in methanol). Has been used extensively in high-throughput screens in fluorometric p450 activity assays, and is metabolized to the fluorescent metabolite 7-Hydroxy-4-trifluoromethylcoumarin (HFC) with λex=410nm; λem=538nm.

Product References

(1) M. Matsui, et al.; Chem. Ber. 125, 467 (1992) | (2) D.M. Stresser, et al.; Drug Metab. Dispos. 30, 845 (2002) | (3) A.Ghosal, et al.; Biopharm. Drug Dispos. 24, 375 (2003) | (4) M.T. Donato, et al.; Drug Metabol. Dispos. 32, 699 (2004) | (5) M.A. Hummel, et al.; J. Biomol. Scr. 11, 303 (2006) | (6) D. Jacquemin, et al.; J. Chem. Phys. 125, 164324 (2006) | (7) I. Kaminska, et al.; Polymer Test. 55, 310 (2016)

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