Chemodex

7-Methoxy-4-(trifluoromethyl)coumarin

As low as CHF 98.00

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CDX-M0015-M05050 mgCHF 98.00

CDX-M0015-M250250 mgCHF 412.00

Specifications / Handling

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Product Details
Synonyms	MFC; Methyl 4-(trifluoromethyl)umbelliferyl ether
Product Type	Chemical
Properties
Formula	C₁₁H₇F₃O₃
MW	244.17
CAS	575-04-2
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥99% (TLC)
Appearance	White powder.
Solubility	Soluble in ethanol, methanol, DMSO or DMF.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	HAZHUELNIGDYQH-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Fluorescent substrate for oxidoreductases, especially for Cytochrome P450 family members CYP2C9, CYP2C19, and CYP2E1. Spectral data: λex=333nm; λem=416nm (in methanol). Has been used extensively in high-throughput screens in fluorometric p450 activity assays, and is metabolized to the fluorescent metabolite 7-Hydroxy-4-trifluoromethylcoumarin (HFC) with λex=410nm; λem=538nm.

Product-specific References

(1) M. Matsui, et al.; Chem. Ber. 125, 467 (1992) | (2) D.M. Stresser, et al.; Drug Metab. Dispos. 30, 845 (2002) | (3) A.Ghosal, et al.; Biopharm. Drug Dispos. 24, 375 (2003) | (4) M.T. Donato, et al.; Drug Metabol. Dispos. 32, 699 (2004) | (5) M.A. Hummel, et al.; J. Biomol. Scr. 11, 303 (2006) | (6) D. Jacquemin, et al.; J. Chem. Phys. 125, 164324 (2006) | (7) I. Kaminska, et al.; Polymer Test. 55, 310 (2016)

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