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Chemodex
8-Methoxypsoralen
177
CHF
CHF 177.00
In stock
CDX-M0156-G0055 gCHF 177.00
| Product Details | |
|---|---|
| Synonyms | 8-MP; 8-MOP; 8-Methoxy-6,7-furanocoumarin; 9-Methoxyfuro[3,2-g][1]benzopyran-7-one; 5-Demethoxyisoimpinellin; Ammoidin; Methoxsalen; Xanthotoxin |
| Product Type | Chemical |
| Properties | |
| Formula | C12H8O4 |
| MW | 216.19 |
| CAS | 298-81-7 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to yellow powder. |
| Solubility | Soluble in acetic acid or water (slightly). |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | QXKHYNVANLEOEG-UHFFFAOYSA-N |
| Smiles | COC1=C2OC=CC2=CC2=C1OC(=O)C=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). Has more potency than 5-MOP, 5-OH-P, DH-8-MOP and psoralen in inhibiting CYP2B1 (cytochrome P-450 2B1). Completely inhibits the metabolism of nicotine in vitro. Inhibits the metabolism of caffeine. Methoxsalen is a drug with photoactivating properties used to treat psoriasis, eczema, vitiligo and some cutaneous lymphomas in conjunction with exposing the skin to UVA light. Upon photoactivation, ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms.
Product References
(1) A. Lassus, et al.; Photodermatol. 1, 170 (1984) | (2) F.A. de Wolff, et al.; Clin. Pharmacokinet. 11, 62 (1986) | (3) G. Labbe, et al.; Biochem. Pharmacol. 36, 907 (1987) | (4) D.C. Mays, et al.; Clin. Pharmacol. Ther. 42, 621 (1987) | (5) G. Labbe, et al.; J. Pharmacol. Exp. Ther. 250, 1034 (1989) | (6) H.G. Jeong, et al.; BBRC 208, 1124 (1995) | (7) J.H. Gwang; Cancer Lett. 109, 115 (1996) | (8) M. Farhadi, et al.; Cell J. 15, 348 (2014) | (9) D. Bagdas, et al.; Neuropharmacol. 85, 67 (2014)
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