CHF 95.00
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CDX-T0003-G0011 gCHF 95.00
CDX-T0003-GG252.5 gCHF 189.00
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Product Details
Synonyms 4-(Trifluoromethyl)umbelliferone
Product Type Chemical
Formula C10H5F3O3
MW 230.14
CAS 575-03-1
Source/Host Chemicals Synthetic.
Purity Chemicals ≥98% (NMR)
Appearance White to off-white crystalline powder.
Solubility Soluble in alcohols, DMSO or DMF.
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Smiles OC1=CC=C2C(OC(=O)C=C2C(F)(F)F)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

This compound is widely used as a substrate for Cytochrome P450. It has also been used as a marker substrate for assessment of Drug-Drug interactions to multiple isoforms of UDP-glucuronosyltransferases. Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.

Product References

(1) P. Baranczewski; Assay and Drug Developm. Techn. 2(4), 345 (2004) | (2) A.B. Renwick; Xenobiotica 30(10), 955 (2000) | (3) G. Luyten et al.; J. Histochem. Cytochem. 33, 965 (1985)

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