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Chemodex
7β-Hydroxycholesterol
162
CHF
CHF 162.00
In stock
CDX-H0116-M0055 mgCHF 162.00
CDX-H0116-M01010 mgCHF 272.00
CDX-H0116-M100100 mgCHF 1'289.00
| Product Details | |
|---|---|
| Synonyms | 5-Cholestene-3β,7β-diol |
| Product Type | Chemical |
| Properties | |
| Formula | C27H46O2 |
| MW | 402.65 |
| CAS | 566-27-8 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to white-yellow powder. |
| Solubility | Soluble in ethanol, chloroform or methanol. |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | OYXZMSRRJOYLLO-KGZHIOMZSA-N |
| Smiles | [H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Oxysterole. Cholesterol oxidation metabolite. Induces cell death/apoptosis and shows antiproliferative activity against cancer cells, involving mitochondrial perturbation, oxidative stress and lysosomal destabilization. Its membrane organizing properties may have implications in Alzheimer’s disease. Increased levels correlate with risk of cardiovascular diseases including atherosclerosis. Shown to have proinflammatory activity.
Product References
(1) S. Lemaire, et al.; FEBS Lett. 440, 434 (1998) | (2) G. Lizard, et al.; Arterioscler. Thromb. Vasc. Biol. 19, 1190 (1999) | (3) J. Wang, et al.; Biochem. 43, 1010 (2004) | (4) S. Roussi, et al.; Cell Death Differ. 12, 128 (2005) | (5) K.A. Kang, et al.; Biol. Pharm. Bull. 28, 1377 (2005) | (6) S. Roussi, et al.; Apoptosis 12, 87 (2007) | (7) S. Lordan, et al.; Int. J. Toxicol. 27, 279 (2008) | (8) W. Li, et al.; Free Radic. Res. 43, 1072 (2009) | (9) L. Trevisi, et al.; J. Vasc. Res. 47, 241 (2010) | (10) C. Mascia, et al.; Free Radic. Biol. Med. 49, 2049 (2010)
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