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AdipoGen Life Sciences
anti-Irisin, pAb (IN102)
460
CHF
CHF 460.00
In stock
AG-25B-0027-C100100 µgCHF 460.00
| Product Details | |
|---|---|
| Synonyms | Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved) |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant irisin. |
| Application |
Western Blot: (1:1'000) |
| Crossreactivity |
Human Monkey Mouse Rat |
| Specificity |
Recognizes human, mouse, rat, monkey Irisin and FNDC5. Detects endogenous mouse and human Irisin [Lit: 1-2]. |
| Purity Detail | Epitope-affinity purified. |
| Concentration | Lot dependent. |
| Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
Product References
- Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway: C.D. Wrann, et al.; Cell Metab. 18, 649 (2013)
- Detection and quantitation of circulating human irisin by tandem mass spectrometry: M.P. Jedrychowski, et al.; Cell Metab. 22, 734 (2015)
- Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis: X. Li, et al.; Front. Cell Dev. Biol. 9, 703670 (2021)
- AAV-mediated skeletal muscle specific irisin expression does not contribute to weight loss in mice: BB. Bagon, et al.; BBRC 682, 111 (2023)
- Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice: N.H. Witmer, et al.; Cell Metab. 36, 879 (2024)
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