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AdipoGen Life Sciences
Psammaplin A
150
CHF
CHF 150.00
In stock
AG-CN2-0088-C100100 µgCHF 150.00
| Product Details | |
|---|---|
| Synonyms | Bisprasin; NSC-614495 |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H24Br2N4O6S2 |
| MW | 664.4 |
| CAS | 110659-91-1 |
| Source/Host Chemicals | Isolated from Psammaplysilla purpurea. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO, MeOH/H2O(40:60) or CH3CN/H2O(40:60). Insoluble in water. |
| InChi Key | LMAFSGDNHVBIHU-HJTNQMAYSA-N |
| Smiles | O\N=C(\CC1=CC(Br)=C(O)C=C1)C(=O)NCCSSCCNC(=O)C(\CC1=CC(Br)=C(O)C=C1)=N/O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [1].
- Caffeine-like Ca2+ releaser in heavy sarcoplasmic reticulum (HSR) [2].
- Antifungal [3].
- Chitinase inhibitor [3].
- DNA methyltransferase inhibitor [4].
- Histone deacetylase (HDAC) inhibitor [4, 5].
- Anticancer compound. Angiogenesis suppressor [5].
Product References
- Psammaplin A, a natural bromotyrosine derivative from a sponge, possesses the antibacterial activity against methicillin-resistant Staphylococcus aureus and the DNA gyrase-inhibitory activity: D. Kim, et al.; Arch. Pharm. Res. 22, 25 (1999)
- Bisprasin, a novel Ca(2+) releaser with caffeine-like properties from a marine sponge, Dysidea spp., acts on Ca(2+)-induced Ca(2+) release channels of skeletal muscle sarcoplasmic reticulum: A. Suzuki, et al.; J. Pharmacol. Exp. Ther. 292, 725 (2000)
- Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax: J.N. Tabudravu, et al.; Bioorg. Med. Chem. 10, 1123 (2002)
- Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase: I.C. Pina, et al.; J. Org. Chem. 68, 3866 (2003)
- Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro: J.S. Shim, et al.; Cancer Lett. 203, 163 (2004)
- Psammaplin A is a natural prodrug that inhibits class I histone deacetylase: D.H. Kim, et al.; Exp. Mol. Med. 39, 47 (2007)
- Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets: M.B. Baud, et al.; J. Med. Chem. 55, 1731 (2012)
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