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Chemodex
GSH-OEt
75
CHF
CHF 75.00
In stock
CDX-G0006-M100100 mgCHF 75.00
CDX-G0006-M500500 mgCHF 299.00
CDX-G0006-G0055 gCHF 2'239.00
| Product Details | |
|---|---|
| Synonyms | Glutathione reduced ethyl ester; N-(N-L-γ-Glutamyl-L-cysteinyl)glycine-3-ethyl ester |
| Product Type | Chemical |
| Properties | |
| Formula |
C12H21N3O6S |
| MW | 335.38 |
| CAS | 92614-59-0 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥90% (HPLC) |
| Appearance | Solid. |
| Solubility | Soluble in DMSO (20mg/ml) or water (>100mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | JKRODHBGNBKZLE-YUMQZZPRSA-N |
| Smiles | CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione (GSH) and glutathione ethyl ester (GSH-OEt) supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.
Product References
(1) M. A. Retamal et al.; PNAS, 103(12), 4475 (2006) | (2) C. Leeuwenburgh et al.; J. Nutr., 128(12), 2420 (1998) | (3) K.Nishida et al.; Res. Commun. Chem. Pathol. Pharmacol. 82, 49 (1993)
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