CHF 108.00
In stock
CDX-T0103-M0011 mgCHF 108.00
CDX-T0103-M0055 mgCHF 272.00
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Product Details
Product Type Chemical
Source/Host Chemicals Synthetic
Purity Chemicals ≥98% (HPLC)
Appearance Deep blue, violet crystals.
Solubility Soluble in DMSO. Poor solubility in water (1µM).
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Solubility: Due to the low solubility in water, we recommend preparing a JC-10 stock solution in DMSO (1mg/ml) which then can be further diluted in the aqueous buffer of choice. The DMSO stock solution of the compound is stable for at least 1 month when stored at -20°C. Avoid repeated freeze-thaw cycles which can damage the compound. Prepare the working solution on the day of use. The working solution can not be restored or frozen and should be used within one day.

Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Derivative of JC-1 useful for determining mitochondrial membrane potential by flow cytometry, fluorescence microscopy and in microplate-based fluorescent assays. Accumulates in mitochondria, selectively generating an orange J-aggregate emission profile (570 nm) in healthy cells. Upon cell injury, as membrane potential decreases, JC-10 monomers are generated, resulting in a shift to green emission (520 nm). Shows improved solubility compared to JC-1 in aqueous media and an ability to detect subtler changes in mitochondrial membrane potential loss. Spectral data: λex 510 nm| λem 525.

Product References

(1) L. Donaghy, et al.; PLoS One 7, e46594 (2012) | (2) C.C. Chen, et al.; Drug Des. Dev. Ther. 8, 459 (2014) | (3) S. Yokokura, et al.; BMC Cancer 26, 882 (2014) | (4) C. Filippi, et al.; Nanotoxicology 9, 126 (2015)

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