102 CHF CHF 102.00
CDX-T0103-M0011 mgCHF 102.00
CDX-T0103-M0055 mgCHF 255.00
|Purity Chemicals||≥98% (HPLC)|
|Appearance||Deep blue, violet crystals.|
|Solubility||Soluble in DMSO or water.|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
Derivative of JC-1 useful for determining mitochondrial membrane potential by flow cytometry, fluorescence microscopy and in microplate-based fluorescent assays. Accumulates in mitochondria, selectively generating an orange J-aggregate emission profile (570 nm) in healthy cells. Upon cell injury, as membrane potential decreases, JC-10 monomers are generated, resulting in a shift to green emission (520 nm). Shows improved solubility compared to JC-1 in aqueous media and an ability to detect subtler changes in mitochondrial membrane potential loss. Spectral data: λex 510 nm| λem 525.
(1) L. Donaghy, et al.; PLoS One 7, e46594 (2012) | (2) C.C. Chen, et al.; Drug Des. Dev. Ther. 8, 459 (2014) | (3) S. Yokokura, et al.; BMC Cancer 26, 882 (2014) | (4) C. Filippi, et al.; Nanotoxicology 9, 126 (2015)