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AdipoGen Life Sciences
anti-Irisin, pAb (IN102) (Biotin)
490
CHF
CHF 490.00
In stock
AG-25B-0027B-C100100 µgCHF 490.00
Product Details | |
---|---|
Synonyms | Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved) |
Product Type | Polyclonal Antibody |
Properties | |
Source/Host | Rabbit |
Immunogen/Antigen | Recombinant irisin. |
Label/Conjugates | Biotin |
Application |
Western Blot: (1:1'000) ELISA:(Detection) |
Crossreactivity |
Human Monkey Mouse Rat |
Specificity | Recognizes human, mouse, rat, monkey Irisin and FNDC5. Detects endogenous mouse and human Irisin [Lit: 1-2]. |
Purity Detail | Protein A-affinity purified. |
Concentration | 0.5 mg /ml |
Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
Description
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
Product References
- Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway: C.D. Wrann, et al.; Cell Metab. 18, 649 (2013)
- Detection and quantitation of circulating human irisin by tandem mass spectrometry: M.P. Jedrychowski, et al.; Cell Metab. 22, 734 (2015)
- Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis: X. Li, et al.; Front. Cell Dev. Biol. 9, 703670 (2021)
- AAV-mediated skeletal muscle specific irisin expression does not contribute to weight loss in mice: BB. Bagon, et al.; BBRC 682, 111 (2023)
- Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice: N.H. Witmer, et al.; Cell Metab. 36, 879 (2024)